Translational Research: Where Do We Go From Here?

Full access

Nephrologists do a lot to improve and prolong the lives of their patients, but we all wish we could do more. No magic fairy will grant our wishes. They will only be fulfilled through painstaking research.

In this section, Speth and Wood speak as scientist and patient about the importance of animal models in the development of therapies for chronic kidney disease. Animal research is still a key component of procedure and drug development that benefits people and animals. Barker, Story, and Wathen present their thoughts on statistical evaluations and the conflict between Frequentists versus Bayesian analyses. Take heed: there is a section of hard-core mathematics, but the differences will be otherwise apparent. Mahan and Smoyer examine a common disorder, pediatric nephrotic syndrome, and the need for multicenter study groups to change its long-term outcomes. They specifically review their own experience with the Mid-West Pediatric Nephrology Consortium and other clinical study groups.

Solving kidney problems requires better understanding of basic processes of biology, new therapeutic targets and the drugs to modulate them, and studies of populations with and without kidney disorders. Research is a complex dance of ideas from the clinic to the laboratory bench and then back to the bedside. Progress depends on robust inquiry at all levels of our perception and imagination.

Pascale Lane, editor in chief, ASN Kidney News