The kidneys play a crucial role in filtering waste and toxins from the blood to maintain overall health. Exposure to various environmental and chemical toxins can disrupt kidney development and impair kidney function, leading to severe health consequences. This special section of Kidney News explores the complex intersection between toxicology and kidney health, spanning topics from the role of the nephrologist in drug safety to how to treat patients who are poisoned by various agents. Kidney News thanks Prakash Gudsoorkar, MD, FASN, for selecting and coediting these articles.