The Future of Acute Kidney Injury Research: Key Trends in 2024

Jia H. Ng Jia H. Ng, MD, MSCE, is an assistant professor of medicine with the Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, Hempstead, NY.

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Acute kidney injury (AKI) is a critical health issue globally. Heading into 2024, research in this field offers promising avenues for understanding and managing AKI. This article outlines three key research areas set to advance AKI knowledge and treatment.

Basic science: Exploring kidney cell dynamics

In 2024, scientists are focusing on the cellular and molecular dynamics of kidney cell death and recovery (14). Breakthroughs in this domain could revolutionize how we approach AKI treatment. Key focuses include kidney fibrosis and the processes of adaptive repair and maladaptive repair—the body's response to AKI. These insights have the potential for groundbreaking treatments that prevent cell death or enhance repair post-injury.

Artificial intelligence: Revolutionizing AKI prediction and management

Building on the work presented at ASN Kidney Week 2023, artificial intelligence (AI) and machine learning are redefining AKI research (57). We saw researchers developing predictive models through different stages of AKI, from detecting AKI to managing AKI. Specific examples include models that are designed to identify high-risk individuals early, complex algorithms for analyzing vast data sets, personalized diuretic strategies, dynamic risk assessment, and AI-guided dosing in AKI treatment. Such advancements could lead to earlier interventions, reducing AKI severity or preventing it.

Clinical research: A holistic, patient-centered approach

Current AKI research is adopting a holistic, patient-centered perspective, focusing on physical, emotional, and cognitive impacts (8). This approach recognizes AKI's broader effects on quality of life and explores interventions targeting the entire health spectrum of patients. A significant study in this domain is the IMPROVE AKI Cluster-Randomized Trial (9), which investigated the sustainability of team-based coaching in patient care. The AKINow Recovery Workgroup ( is working on projects to improve post-AKI transition of care.

AKI research in 2024 will span basic science, AI, and clinical research (Figure 1). This synergy will result in more effective prevention and treatment strategies, improving outcomes for patients with AKI.

Figure 1
Figure 1

AKI research: What to watch for in 2024

Citation: Kidney News 16, 1


The authors report no conflicts of interest.