Infection-related glomerulonephritis (IRGN) is typically considered an immune-complex glomerulonephritis. Previously known only as “post-streptococcal” glomerulonephritis, it is now recognized that any infection can trigger immunologically mediated glomerular injury, which can even occur concurrently with the infection that precipitated it.
… [A]ny infection can trigger immunologically mediated glomerular injury, which can even occur concurrently with the infection that precipitated it.
Observational data suggest that a significant number of patients with IRGN experience incomplete or even non-recovery of kidney function (1–3). Consequently, the possibility that the natural history of the disease might be amenable to manipulation with broad immunosuppression using corticosteroids was entertained by many authors (4–7). In fact, steroid administration became standard clinical practice in many clinical settings, despite the absence of clear evidence of its benefit (8, 9).
- 1. ↑
Shankar M, et al. Infection-related glomerulonephritis: A retrospective observational study from South India. Clin Nephrol 2022; 98:101–106. doi: 10.5414/CN110835
Trivedi M, et al. The epidemiology, clinical features, and outcome of infection-related glomerulonephritis from East India: A single center experience. Indian J Nephrol 2017; 27:307–312. doi: 10.4103/ijn.IJN_280_16
- 3. ↑
Arivazhagan S, et al. Clinicopathological profile and outcome of adult infection-related glomerulonephritis: A prospective follow-up study. Natl Med J India 2020; 33:260–264. doi: 10.4103/0970-258X.317465
- 4. ↑
Kapadia AS, et al. Postinfectious glomerulonephritis: Is there a role for steroids? Indian J Nephrol 2011; 21:116–119. doi: 10.4103/0971-4065.82141
Sathi S, et al. Postinfectious glomerulonephritis with crescents in an elderly diabetic patient after acute gastroenteritis: Case report. Case Rep Nephrol Dial 2019; 9:64–71. doi: 10.1159/000500304
Yang TJ, et al. Role of steroids in post-streptococcal glomerulonephritis without crescents on renal biopsy. Cureus 2018; 10:e3150. doi: 10.7759/cureus.3150
- 7. ↑
Baikunje S, et al. Post-infectious glomerulonephritis with crescents in adults: A retrospective study. Clin Kidney J 2016; 9:222–226. doi: 10.1093/ckj/sfv147
- 8. ↑
Sakthirajan R, et al. Crescentic infection related glomerulonephritis in adult and its outcome. Saudi J Kidney Dis Transpl 2018; 29:623–629. doi: 10.4103/1319-2442.235169
- 9. ↑
Nasr SH, et al. Acute postinfectious glomerulonephritis in the modern era: Experience with 86 adults and review of the literature. Medicine (Baltimore) 2008; 87:21–32. doi: 10.1097/md.0b013e318161b0fc
- 10. ↑
Arivazhagan S, et al. Efficacy of corticosteroids in infection-related glomerulonephritis—a randomized controlled trial. Kidney Int Rep 2022; 7:2160–2165. doi: 10.1016/j.ekir.2022.07.163
- 11. ↑
Chauvet S, et al. Anti-factor B antibodies and acute postinfectious GN in children. J Am Soc Nephrol 2020; 31:829–840. doi: 10.1681/ASN.2019080851.z