Drinking at least two cups of coffee per day has a protective effect against acute kidney injury (AKI), reports a study in Kidney International Reports.
The analysis included 14,207 adults, aged 45 to 64 years, from the population-based Atherosclerosis Risk in Communities (ARIC) study. Coffee consumption was assessed at a single study visit using a semiquantitative food-frequency questionnaire and was evaluated for association with incident AKI.
Of the participants, 27% never drank coffee, 14% drank less than one cup per day, 19% drank one cup per day, 23% drank two or three cups per day, and 17% drank more than three cups per day. Several of the following health factors were associated with higher coffee consumption: absence of diabetes, lower body mass index (BMI), lower systolic and diastolic blood pressure, and higher daily energy intake. Estimated glomerular filtration rate (eGFR) was slightly lower for participants who drank more coffee.
Associations of coffee consumption with lower risk of AKI were significant for two to three cups and for three or more cups per day. The trends remained significant after adjustment for age, sex, race, education, daily energy intake, physical activity, smoking, alcohol use, diet quality, systolic blood pressure, diabetes status, anti-hypertensive therapy, eGFR, and BMI.
Coffee is widely consumed worldwide and has been linked to a wide range of health benefits. In a previous ARIC analysis, higher coffee consumption was associated with a lower incidence of chronic kidney disease.
Although emphasizing the need for more research, the investigators conclude, “Our data support chronic coffee consumption as an opportunity for cardiorenal protection through diet, particularly for the prevention of AKI hospitalizations or procedures” [Tommerdahl KL, et al. Coffee consumption may mitigate the risk for acute kidney injury: Results from the Atherosclerosis Risk in Communities (ARIC) study. Kidney Int Rep, published online ahead of print May 5, 2022. https://www.sciencedirect.com/science/article/pii/S2468024922013699].