Young Investigator Recognized for Contributions in Genetic Studies of Kidney Disease

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Krzysztof Kiryluk, MD

Citation: Kidney News 13, 10/11

The American Society of Nephrology-American Heart Association Donald W. Seldin Young Investigator Award will be presented to Krzysztof Kiryluk, MD, MS, who will speak on “Genetic Discovery in IgA Nephropathy” on Friday, November 5.

Dr. Kiryluk is associate professor of medicine in the Division of Nephrology at Columbia University in New York City.

His research aims to define genetic factors that contribute to the risk of kidney disease. He leads several large collaborative national and international genetic studies of glomerular disorders, including IgA nephropathy and membranous nephropathy. He is investigating genetic regulators of IgA production and O-glycosylation and their relationship to human health and disease.

Dr. Kiryluk uses functional genomics and systems genetics approaches to elucidate molecular mechanisms underlying inherited kidney disorders. He is also developing novel approaches to identifying genetic predictors of kidney allograft rejection using genome-wide donor-recipient compatibility studies.

Some of Dr. Kiryluk's interests fall at the interface of research and clinical care. He is developing new informatics methods to harness the power of clinical and molecular big data to enhance genetic discovery and improve clinical care of kidney patients. On this front, he is leading several local and national precision medicine efforts, including molecular studies of acute kidney injury in the precision medicine project of the National Institute of Diabetes and Digestive and Kidney Diseases and the Electronic Medical Records and Genomics (eMERGE) consortium of the National Human Genome Research Initiative.

Dr. Kiryluk is also involved in education. He directs the renal physiology and pathophysiology course for medical students at the Columbia College of Physicians & Surgeons, co-directs the Columbia TL1 training program in precision medicine for graduate and postdoctoral students, and co-leads the Columbia Clinical and Translational Science program's precision medicine resource.

He is a member of the editorial boards of JASN and Kidney International. He is currently guest editor for cases in precision medicine for the Annals of Internal Medicine.

He received an Innovations in Kidney Education Award and a Carl W. Gottschalk Research Scholar Award from ASN and a Young Investigator Award from the American Society of Hypertension.

Dr. Kiryluk received his medical degree from the Columbia College of Physicians & Surgeons and then completed an internal medicine residency at Massachusetts General Hospital and a nephrology fellowship at New York-Presbyterian Hospital, Columbia University. He received a master's in biostatistics from the Columbia University Mailman School of Public Health.