Scientist to Address the Use of Precision Medicine to Treat Kidney Disease

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Matthias Kretzler, MD

Citation: Kidney News 13, 10/11

A leading researcher in bioinformatics will deliver the Barry M. Brenner, MD, Endowed Lectureship on “Applied Precision Medicine in Glomerular Diseases” on Thursday, November 4.

The speaker will be Matthias Kretzler, MD, who is the Warner-Lambert/Parke-Davis professor of internal medicine, nephrology, and computational bioinformatics at the University of Michigan Medical School in Ann Arbor.

Dr. Kretzler's research is aimed at defining chronic kidney disease in mechanistic terms and using this knowledge for targeted therapeutic interventions. In pursuit of this goal, his research team has developed a translational research pipeline centered on integrated systems-biology analysis of kidney disease. For over 25 years, the team has built a track record of interdisciplinary integration of large-scale data sets in international research networks in the United States, Europe, China, and sub-Saharan Africa. These studies enable precision medicine across the genotype–phenotype continuum using carefully monitored environmental exposures, genetic predispositions, epigenetic markers, transcriptional networks, proteomic profiles, metabolic fingerprints, digital histological biopsy archives, and prospective clinical disease characterization.

This work has resulted in more than 350 publications describing new disease predictors, de novo drug development, and clinical trials of novel therapeutics in chronic kidney disease.

Dr. Kretzler leads the U54 Nephrotic Syndrome Research Network in the Rare Disease Clinical Research Network II. He is a principal investigator of the coordinating center of the Cure Glomerulonephropathy (CureGN) research network, the National Institutes of Health (NIH) acceleration of medicine in lupus program, and the NIH-funded integrated systems biology approach to diabetic microvascular complications program.

Among his many honors, he has received the Janssen-Cilag Award and the Carl Ludwig Young Investigator Award from the German Nephrology Association, the Mary Jane Kugel Award from the Juvenile Diabetes Research Foundation, and the Young Investigator Award from ASN.

Dr. Kretzler received his MD/PhD equivalent from the University of Heidelberg, Germany. He completed his internal medicine residency and nephrology fellowship at the University of Munich. He completed a research fellowship in physiology and nephrology at the University of Michigan.