Blood pressure (BP) is a dynamic entity and, just like many other orders in nature, is affected by variability. Studies have shown variability in an individual’s BP over seconds, minutes, and days. This variability has been found to correlate with morbidity and mortality events. This review is intended to highlight some basic concepts of this entity with a focus on measures of variability and outcomes. The types of BP variability are shown in Table 1 (1).
Bilo G, et al.. A new method for assessing 24-h blood pressure variability after excluding the contribution of nocturnal blood pressure fall. J Hypertens 2007; 25:2058–2066.
Mena L, et al.. A reliable index for the prognostic significance of blood pressure variability. J Hypertens 2005; 23:505–511.
Muntner P, et al.. Visit-to-visit variability of systolic blood pressure and coronary heart disease, stroke, heart failure and mortality: A cohort study. Ann Intern Med 2015; 163:329–338.
Palatini P, et al.. Added predictive value of night time blood pressure variability for cardiovascular events and mortality: The Ambulatory Blood Pressure International Study. Hypertension 2014; 64:487–493.
Rothwell PM, et al.. Effects of beta blockers and calcium-channel blockers on within-individual variability in blood pressure and risk of stroke. Lancet Neurol 2010; 9:469–480.
Hoshino A, Nakamura T, Matsubara H. The bedtime administration ameliorates blood pressure variability and reduces urinary albumin excretion in amlodipine-olmesartan combination therapy. Clin Exp Hypertens 2010; 32:416–422.