Michael Mauer, MD, will speak on “Diabetic Kidney Disease: Structural–Functional Relationships and the Possibilities of Cure” in the Barry M. Brenner, MD, Endowed Lectureship on Thursday, Nov. 7.
Dr. Mauer is professor of medicine at the University of Minnesota in Minneapolis, where he is a faculty member in both the division of pediatric nephrology and the division of renal diseases and hypertension.
His early clinical research involved the development of hemodialysis methods and kidney transplant strategies and protocols for infants and small children, an interest that continued for years. He began his basic research with studies of mesangial cell function in rats. He then performed structural and functional studies of diabetic nephropathy models in rats and mice.
His lab developed quantitative morphometric electron microscopic methods to quantify diabetic nephropathy lesions in rats that were subsequently applied to research renal biopsies, primarily in type 1 diabetes patients. Over the next four decades, he conducted studies elucidating the structural and functional relationships in diabetic nephropathy, diabetic nephropathy natural history studies, and clinical trials with diabetic nephropathy structural primary endpoints. His recent studies have also included Pima Indian, Japanese, and Caucasian patients with type 2 diabetes. He also performed a series of in vitro molecular studies using cultured skin fibroblasts from patients with type 1 diabetes that elucidated potential pathophysiological pathways of interest.
For the past 12 years, he has pursued quantitative structural studies of renal biopsies in Fabry disease. These studies have helped to define an important role for the podocyte in the kidney complications in this disorder.
Dr. Mauer has had continuous National Institutes of Health funding for more than four decades. He has published more than 350 peer-reviewed articles and 90 book chapters. He serves on many editorial boards, including those of Diabetes Care, International Journal of Pediatric Nephrology, Journal of Pediatric Nephrology, Kidney International, and Pediatrics.
Dr. Mauer graduated from McGill Medical School in Montreal, Canada. He completed his residency in pediatrics at McGill and the University of Colorado. After his fellowship in pediatric nephrology at the University of Minnesota, he joined the faculty there. He was co-director of the division of pediatric nephrology from 1992 to 2009.