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Teresa K. Chen and Derek M. Fine

Intravascular iodinated contrast has historically been considered a risk factor for acute kidney injury (AKI), particularly among individuals with underlying chronic kidney disease (1). Recent studies, however, have suggested that incidence of contrast-induced nephropathy (CIN) may not be as frequent as previously thought (2,3). In this commentary, we argue that contrast material can often be safely used without increased risk of AKI, even among individuals with underlying kidney disease.

Although the definition can vary from study to study (4), CIN is usually characterized by a 0.5 mg/dL rise in serum creatinine from