Podocytopathies are a group of kidney diseases caused by direct or indirect injury to the glomerular podocytes, resulting in proteinuria. Examples of podocytopathies are minimal change disease (MCD), focal segmental glomerulosclerosis (FSGS), and collapsing glomerulopathy (CG) (1). T-regulatory cell dysfunction and the podocyte proteins CD80 (2)/angiopoietin-like protein 4 (Angptl4) (3) have been shown to participate in the pathogenesis of MCD. An insult to the network of the visceral and parietal epithelial cells of the glomerulus by the immune system or a genetic defect is thought to be responsible for the development of primary FSGS
The prevalence of malignancy in patients with membranous nephropathy (MN) ranges from 4% to 10% (1, 2). In adults, MN is the most common cause of nephrotic syndrome outside of diabetes and is well described but not well studied in patients with cancer.
In a recent article by Thet and colleagues (3) in Translational Oncology, the authors impart on an update on cancer risks in patients with a glomerular diseases. Thet et al. (3) used MN as a prototype to understand malignancy-related glomerular disease. Malignancy-related MN is a disease of