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Mythri Shankar
1. Collapsing glomerulopathy (CG)—high-dose pamidronate

Pamidronate has been found to be associated with CG in patients with multiple myeloma and breast cancer. In these patients, pamidronate is used in higher doses to prevent skeletal complications. It is hypothesized that pamidronate affects the glomerular epithelial cells (1).

Light microscopy: Jones silver stain, proliferation of visceral epithelial cells and collapse of glomerulus known as collapsing focal segmental glomerulosclerosis (FSGS). Image credit: K.S. Vinay.

2. Thrombotic microangiopathy (TMA)—bevacizumab; anti-vascular endothelial growth factor (anti-VEGF) agent

TMA can occur any time after the initiation of treatment with anti-VEGF agents. TMA is rarely systemic

Mythri Shankar

Hippocrates. Engraving based on drawing by Peter Paul Rubens. National Library of Medicine, Bethesda, MD (CC by 4.0).

Portrait of Richard Bright from Thomas Joseph Pettigrew, Medical Portrait Gallery, vol. 2 (1838).

Nephrology is a relatively young specialty. It emerged in the second half of the 20th century, with the rise of kidney biopsy, dialysis, and transplantation. Although kidneys have been studied since antiquity, stones and obstruction were a dominant focus. Urology books from 1739 mention the only treatment of anuria as bladder catheterization (1). So, how did the study of glomerular diseases rise as a cornerstone of

Mythri Shankar and Paolo Nikolai So

Mythri Shankar's “The Birth of Understanding Glomerulonephritis” in the February Kidney News is a comprehensive walk through the history of our understanding of kidney diseases. Pivotal points were the discovery of the glomerulus and subsequent recent insights into the pathobiology and genetics of glomerular diseases.

The visual here, prepared by Paolo Nikolai So, MD, pulls it all together.