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Mayuri Trivedi and Kirk N. Campbell

Novel biomarkers have been changing our understanding of glomerular disease physiology by improving our diagnostic and prognostic capabilities while opening the door to more precise therapeutic options. Most notably, the discovery of the anti-phospholipase receptor-2 antibody (anti-PLA2R Ab) in 2009 has facilitated diagnostic algorithms where some patients with high PLA2R titers may not need a kidney biopsy. Titer levels are followed clinically to monitor response to treatment and risk of relapse, whereas novel therapeutics are being developed to specifically inhibit presumed pathogenic properties of PLA2R Abs (1).

Nephrin, an important component of the slit diaphragm, has been one