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Sanjeev Sethi and Fernando C. Fervenza

Membranoproliferative glomerulonephritis (MPGN), also termed mesangiocapillary glomerulonephritis, is a diagnosis based on a glomerular injury pattern common to a heterogeneous group of diseases (1). MPGN is characterized by both an inflammatory (proliferative) and resolving (membrane) phase. Histologically, the proliferative phase is characterized by an increase in mesangial and endocapillary cellularity, and the resolving phase is characterized by an increase in mesangial matrix and capillary wall remodeling with basement membrane material forming a wall, resulting in double contour formation.

Previously, MPGN was classified into MPGN types I, II, and III, based on the ultrastructural location of the electron-dense deposits