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Randy L. Luciano
Membranous nephropathy

Membranous nephropathy (MN) is a common cause of nephrotic syndrome, attributed to approximately 25% of adult patients with nephrotic-range proteinuria or nephrotic syndrome (1). This number is significantly less in children with nephrotic syndrome. The clinical course of MN is insidious, with variable degrees of proteinuria, hypoalbuminemia, and hyperlipidemia that can lead to significant edema and in extreme cases, a rapid loss of kidney function, anasarca, acute kidney injury, and thromboembolic events. The clinical presentation is the resulting immune complex formation on the epithelia side of the glomerular basement membrane (GBM).

MN is classified as primary,