Investigators who are designing clinical trials and preclinical studies have realized that results found in males do not always hold true in females, and that there are clear differences in the sexes that should be considered when preventing and treating a wide variety of health issues. Kidney researchers also note that because female physiology is optimized for successful reproduction—which entails large fluctuations in vascular, hemodynamic, and renal function—it’s likely that female kidneys have important differences from those of males.
With this in mind, a team led by scientists at the Keck School of Medicine of the University of Southern California,
A new study points to factors involved in the reduced likelihood of rejection in liver-kidney transplant recipients compared with solitary kidney transplant recipients.
“For many years, transplant physicians and researchers have known that the liver transplant recipients require less immunosuppression than the recipients of other organs, to prevent rejection,” said Timucin Taner, MD, PhD, a transplant surgeon at the Mayo Clinic and lead author of the Kidney International study. “This has been attributed to the liver being less immunogenic compared to the other commonly transplanted organs; however, the liver itself is an immunologically active organ, so we hypothesized