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Scott Reule and Hassan N. Ibrahim

As donor nephrectomy is entirely performed for the beneficence of the recipient, minimizing surgical morbidity and preserving long-term mortality is a priority. Currently, laparoscopic nephrectomy is associated with less pain, shorter hospital stay and faster return to work, and a calculated mortality rate of 3.1 per 10,000 donors, controlled for age, race, and sex (1,2).

Does kidney donation, with its associated loss of glomerular mass, impart a risk profile similar to that of patients with chronic kidney disease (CKD)? Many studies have demonstrated no significant increase in mortality among donors in comparison to variably matched controls