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Cover Kidney News
Sodium Glucose Co-transporter 2 Inhibitors
Christos Argyropoulos

Reducing the human and financial burden of progressive diabetic kidney disease (DKD) and ESKD stalled after the landmark trials of renin-angiotensin system inhibitors (RASi) in the early 2000s. The recent introduction of sodium glucose co-transporter 2 inhibitors (SGLT-2i) appears to reverse 20 years of stagnation in this area. This short review summarizes the key findings in this emerging success story of nephrology therapeutics.

Of rodents …

According to the Brenner hypothesis (1), hyperfiltration drives nephrons to glomerulosclerosis and eventually leads to chronic kidney disease (CKD) and ESKD. Reducing hyperfiltration has been the major paradigm for slowing the progression