Bone and Mineral Metabolism Expert to Describe FGF23 Research

Isidro B. Salusky


Isidro B. Salusky, MD, will share the results of his current research into the role of fibroblast growth factor 23 (FGF23) in the pathogenesis of chronic kidney disease (CKD) mineral and bone disorder as well as the impact of therapies to treat the disorder on FGF23 production.

He will deliver the Jack W. Coburn, MD, Endowed Lectureship, entitled “Approaches to Reduce FGF23 Levels in CKD Patients,” on Thursday, Nov. 5.

Dr. Salusky is distinguished professor of pediatrics, chief of the division of pediatric nephrology, director of the Clinical and Translational Research Center, and associate dean for clinical research at the David Geffen School of Medicine at UCLA.

Dr. Salusky is a clinical-translational research scientist in the subspecialty field of bone and mineral metabolism in children with CKD working to advance our understanding of the mechanisms of disordered mineral metabolism in these patients. As a result of continuous funding from the National Institutes of Health, his research group has characterized the features of bone diseases across the spectrum of CKD. The group has examined the effects of renal transplantation as well as the skeletal effects of therapy with active vitamin D sterols and phosphate binders. The group has also provided significant groundwork on the relationship between abnormalities of bone and mineral metabolism and vascular calcifications.

Dr. Salusky’s service positions include chairing several committees for the National Kidney Foundation of Southern California, chairing the dialysis outcomes quality initiative of the National Kidney Foundation, and participating in many committees of the American Society of Pediatric Nephrology.

He has served on the editorial boards of many journals, including the Journal of the American Society of Nephrology, American Journal of Kidney Diseases, and Advances in Renal Replacement Therapy.

Among his many awards and recognitions, he has received the president’s award from the National Kidney Foundation. He has published more than 140 peer-reviewed research papers, three books, 60 book chapters, and 290 abstracts.

Dr. Salusky received his medical degree from the National University of Buenos Aires in Argentina and completed a fellowship in pediatric nephrology at the Hopital des Enfants Malades in Paris. He joined the staff at UCLA with an advanced research fellowship in 1979 and has been there ever since.

ASN gratefully acknowledges Amgen for support of the Jack W. Coburn Endowed Lectureship.