Kidney Week 2015

Kidney Week 2015

Living kidney or kidney-pancreas donation rates were highest among Caucasians followed by Hispanics and Asians in a study that looked at the impact of organ transplant candidates’ socioeconomic environment on living donation rates. The findings were reported by Douglas Keith, MD, of the University of Virginia Medical Center at Kidney Week 2015.

In a study that looked at the frequency and severity of early complications after living kidney donation, African Americans had a 26% increased risk of experiencing any complication and a 56% increased risk of experiencing major complications, after appropriate adjustment was made for other factors.

Many African Americans with uncontrolled hypertension do not have recommended food choices in their homes. They also often do not have adequate discussions with their doctors about diet, especially the Dietary Approaches to Stop Hypertension (DASH) diet, according to findings from two studies presented at ASN Kidney Week 2015.

The DASH diet is recommended for the treatment of hypertension, especially among African Americans.

Twenty-seven percent of kidney donors surveyed in a recent study reported at Kidney Week developed new-onset hypertension after donation.

Exposure to lead during pregnancy was linked with higher blood pressure in young children in a study presented at Kidney Week 2015. Exposure to lead during infancy did not seem to impact later blood pressure.

A new streamlined approach for early detection and treatment of acute kidney injury (AKI) reduced mortality by 23 percent in a pilot study presented at ASN Kidney Week 2015 (1). AKI is frequently encountered in the hospital setting, complicating approximately 20 percent of cardiac surgeries worldwide. The STOP-AKI protocol—a combination of electronic alerts, a standardized intervention bundle, and staff and patient engagement—is a replicable model that could help to reduce the global burden of AKI.

A team of investigators led by Morgan Grams, MD, of the CKD Prognosis Consortium recently developed equations to help predict potential kidney donors’ lifetime risk of end stage renal disease (ESRD) on the basis of their demographic and health characteristics before kidney donation.

Patients who received kidney transplants survived longer than age-matched patients who underwent home hemodialysis in two studies presented at Kidney Week.

Previous studies found that kidney failure patients on long-term dialysis tend to die earlier than patients who receive kidney transplants, but none of the studies considered death rates in US patients using alternative forms of dialysis such as home hemodialysis.

Despite evidence supporting hypertension in overweight and obese adolescents as risk factors for heart disease, high blood pressure is underdiagnosed in these teenagers. New research presented at Kidney Week examined the extent of the underdiagnosis.

The late-breaking clinical trials presented at ASN Kidney Week 2015 featured research that could help advance patient care in a wide range of clinical areas—from uremic pruritus in dialysis patients to acute kidney injury (AKI) in the hospital setting to the next frontier in renal replacement therapy. Although some trial outcomes were unfavorable or unexpected, Lynda Szczech, MD, FASN, told ASN Kidney News they still provide an important contribution to the medical literature and clinical care. “Negative trials have value too.

New research presented at ASN Kidney Week 2015 found that use of proton pump inhibitors (PPIs) is associated with increased risk for chronic kidney disease (CKD). PPIs are commonly used to treat acid reflux, stomach ulcers, and other acid-related gastrointestinal conditions.

In one study, PPI users were between 20% and 50% more likely to develop CKD than non-PPI users, even after accounting for baseline differences between users and non-users.