Ion Channel Expert Kleyman to Give Robert W. Schrier Endowed Lecture

Thomas Kleyman


Known for his work on epithelial ion channels, Thomas Kleyman, MD, is this year’s recipient of the Robert W. Schrier Endowed Lectureship. He will give his lecture, “Proteolytic Regulation of ENaC in Health and Disease,” during Friday’s Meeting-Within-a-Meeting on “The Renal Basis of Hypertension and Edema,” held from 1:30 to 3:30 p.m. The ASN welcomes Dr. Kleyman as he addresses the mechanisms by which proteases activate the epithelial sodium channel, as well as the role of proteases in activating the channel in certain disease states.

Dr. Kleyman is professor of medicine, cell biology and physiology, and pharmacology at the University of Pittsburgh, where he also serves as chief of the Renal-Electrolyte Division. He directs the Pittsburgh Center for Kidney Research, a National Institutes of Health (NIH)-funded center established in 2008. His work on epithelial ion channels has advanced our understanding of many disorders.

Most recently, Dr. Kleyman’s research has involved conducting cellular and molecular studies to identify important sites within the epithelial sodium channel’s extracellular domain. These sites play key roles in the modulation of channel activity in response to extracellular factors, including proteases and metal ions. Dr. Kleyman studies mechanisms by which specific proteases, such as furin, activate epithelial sodium channels. He and his colleagues are also investigating mechanisms by which mechanical forces regulate epithelial sodium channels and large conductance calcium-activated potassium channels.

To gain a deeper understanding of the epithelial ion channel, Dr. Kleyman examines the channel in disease states. Inherited mutations in ion channels are responsible for many genetic diseases like cystic fibrosis. Studying the functional interactions between epithelial sodium channels and cystic fibrosis transmembrane conductance regulator chloride channels helps shed light on the disease.

Dr. Kleyman is editor of the American Journal of Physiology: Renal Physiology and has served in an editorial capacity for several scientific journals. He has been granted many awards to continue his work in nephrology, including the Established Investigatorship Award from the American Heart Association from 1991 to 1996, the NIH Merit Award in 2006, and the NIH Director’s Bridge Award in 2008. Dr. Kleyman was elected for membership in the American Society for Clinical Investigation in 1996 and the Association of American Physicians in 2004. He has authored many scientific publications

Dr. Kleyman received his medical degree from Washington University in St. Louis in 1978. He completed his internship and residency in medicine in 1981 and his fellowship in nephrology in 1983, both at the Presbyterian Hospital in New York.