Coburn Endowed Lecturer Quarles to Address Hormone-Bone-Kidney Axis

L. Darryl Quarles


L Darryl Quarles, MD, will present the 6th Annual Jack W. Coburn Endowed Lecture on “FGF23 and its Receptors: Lessons from Studies in Mice.” He will give the lecture during the Basic and Clinical Science Symposium “CKD-MBD and Outcomes,” held Saturday, October 31, from 1:30 to 3:30 p.m.

Dr. Quarles is known for his research on how kidney disease affects other organ systems, such as bone. He is currently the Summerfield Endowed Professor of Nephrology at the University of Kansas Medical Center, where he is director of the Kidney Institute, the division of nephrology, and the National Institutes of Health (NIH) T32 fellowship training program in nephrology.

Dr. Quarles will discuss the fibroblastic growth factor 23 (FGF23) hormone-bone-kidney axis as a conceptual framework for understanding the pathogenesis, diagnosis, and treatment of disorders characterized by high or low levels of phosphates in the blood and urine. Produced by osteocytes in the endocrine organ bone, FGF23 helps to regulate phosphate, vitamin D, and mineral homeostasis.

New knowledge is emerging regarding the complex systems biology surrounding FGF23 regulation and function. In helping to elucidate these studies, Dr. Quarles has investigated the cross-talk between bone and other organs that plays a role in adjusting phosphate balance and bone mineralization in response to changing physiological requirements.

Dr. Quarles has maintained an active NIH-funded research laboratory that studies disorders of mineral metabolism using mouse genetic approaches. In addition to studying the regulation and function of FGF23 in health and in chronic kidney disease, the laboratory also studies the role of polycystins and calcium-sensing receptors in bone, and the differential function of Runx2 isoforms.

Dr. Quarles is an elected member of the American Society of Clinical Investigation and the Association of American Physicians. He has authored more than 148 peer-reviewed articles and 15 book chapters.

Dr. Quarles received his medical degree in 1979 and completed his residency in internal medicine in 1982, both at the University of Alabama, Birmingham. He completed his fellowship in nephrology at Duke University Medical Center in 1985, and was professor of medicine and director of the Bone Center at Duke until 2004.