Winn Lecturer to Discuss Genetics of Glomerular Disease

Andrey S. Shaw, MD
Andrey S. Shaw, MD, will deliver the Michelle P. Winn, MD, Endowed Lectureship on the genetics of human focal and segmental glomerulosclerosis (FSGS) on Friday, Nov. 14.

Dr. Shaw is the Emil R. Unanue Professor of Pathology and Immunology and head of the division of immunobiology at Washington University School of Medicine in St. Louis. He is also an investigator of the Howard Hughes Medical Institute.

Dr. Shaw is known for his contributions to our understanding of T cell signal transduction, protein kinases, and the role of podocytes in glomerular diseases. His interest in podocyte biology began with studies of knockout mice that lack a gene called CD2-associated protein, or CD2AP. Because data show that mutations in CD2AP can lead to human glomerular diseases such as FSGS, his team is using human genetics to define the epistatic network of genes involving CD2AP. FSGS is a disease of podocytes, so the team used bioinformatics to identify only those genes expressed in podocytes. They then selected 3000 genes they believed to be the likeliest epistatic candidates. Their goal is to sequence a set of kidney-specific genes in about 1000 FSGS patients and use statistical methods to analyze the pattern of rare variants in patients vs. controls to assemble a list of potential FSGS disease genes. The researchers expect these genes to be epistatic with CD2AP.

Dr. Shaw is the editor of Molecular and Cellular Biology and on the editorial board of BMC Immunology. He received a MERIT Award and a clinical investigator award from the National Institutes of Health and several distinguished service teaching awards from the medical school classes of Washington University.

He earned his bachelors and medical degrees from Columbia University and completed his residency in anatomic pathology and a postdoctoral fellowship at Yale University. He was an instructor at Yale before joining Washington University in 1991. He serves on the immunology program steering committee and the curriculum committee at Washington University Medical School.

ASN gratefully acknowledges Duke University School of Medicine, the school’s Division of Nephrology, and several individuals for support of the Michelle P. Winn, MD, Endowed Lectureship.