Molecular Mechanisms Expert to Describe Findings on Slowing Cyst Progression

Peter Igarashi

An expert on molecular mechanisms underlying kidney function will deliver the Robert W. Schrier, MD, Endowed Lectureship on the topic “MicroRNAs that Slow Cyst Progression” on Thursday, Nov. 13.

Peter Igarashi, MD, FASN, is professor of internal medicine and pediatrics at the University of Texas Southwestern Medical Center in Dallas, where he holds the Robert Tucker Hayes Distinguished Chair in Nephrology. Dr. Igarashi is also director of the University of Texas Southwestern O’Brien Kidney Research Core Center.

Dr. Igarashi began his research career by investigating the molecular mechanisms underlying kidney-specific gene expression, which led to studies of transcriptional regulation of kidney development. He discovered the central role of the transcription factor HNF-1β in the expression of cystic disease genes and elucidated the molecular mechanisms by which mutations of HNF-1β produce kidney cysts and congenital kidney malformations.

His group has generated unique strains of mice that have been widely used for tissue-specific and inducible gene targeting in the kidney. In addition, Dr. Igarashi has studied the role of the primary cilium in the pathogenesis of polycystic kidney disease. His group was the first to demonstrate prospectively that the loss of the primary cilium was sufficient to produce kidney cysts. In related work, his laboratory has defined the relative contributions of bone marrow-derived stem cells and resident kidney cells in tubular regeneration following acute kidney injury. This work has led to Dr. Igarashi publishing more than 100 articles and book chapters.

Dr. Igarashi has served on the editorial boards of the American Journal of Physiology-Renal Physiology and Journal of Clinical Investigation as well as an associate editor of the Journal of the American Society of Nephrology. He has served on many study sections and grant review committees of the American Heart Association, National Kidney Foundation, and National Institutes of Health. Active in several national and international nephrology academic societies, he was the program chair of the 2008 ASN annual meeting.

Dr. Igarashi received an investigator award from the American Heart Association and a MERIT award from the National Institutes of Health.

Dr. Igarashi earned his MD degree from the University of California, Los Angeles, did his residency in internal medicine at the University of California, Davis Medical Center, and was a fellow in nephrology at the Yale University School of Medicine. He joined the faculty of Yale in 1987 and was recruited by the University of Texas Southwestern Medical Center in 1999.

ASN gratefully acknowledges Otsuka America Pharmaceutical, Novartis, Astellas Pharma US, and several individuals for support of the Robert W. Schrier, MD, Endowed Lectureship.