Findings

The roles of obesity and pre-existing kidney disease make it difficult to assess the true nature of the association between preeclampsia and end stage renal disease (ESRD), concludes a report in the American Journal of Kidney Diseases.

Early experience under the revised kidney allocation system (KAS) shows continued quick access to high-quality deceased-donor organs for prior living donors (PLDs), reports a study in the American Journal of Transplantation.

The percentage of Americans with normal body weight but cardiometabolic abnormalities is higher in racial/ethnic minority groups—especially South Asians and Hispanics, reports a study in Annals of Internal Medicine.

 

Even children can face considerable inequities when it comes to receiving transplants.

Two recent papers draw attention to some clinically significant health risks for patients with sickle cell trait (SCT)—an inherited blood disorder affecting up to 10% of African Americans.

African Americans with SCT have lower levels of hemoglobin A1c—which may place them at risk of delayed or missed diagnosis of diabetes and prediabetes, according to a study in the Journal of the American Medical Association (J Am Med Assoc 2017; 317:507–515).

Nearly two-thirds of children with type 1 diabetes hospitalized for diabetic ketoacidosis (DKA) will develop acute kidney injury (AKI), suggests a study in JAMA Pediatrics.

Currently available data cannot establish the safety and efficacy of osteoporosis medications for patients with chronic kidney disease (CKD), concludes a meta-analysis in Annals of Internal Medicine.

Endophilin is critical to the development and maintenance of podocyte function in the kidney. This is the conclusion of Keita Soda, PhD, and co-workers from Yale University, who presented work at the Hot Science session at Kidney Week 2012 that described the connection between the protein endophilin and the synaptic proteins dynamin and synpatojanin 1, as well as the vital role endophilin plays in the formation and maintenance of the glomerular filtration barrier.

Although effects on relative versus absolute risk differ, low estimated glomerular filtration rate (eGFR) and high albuminuria are linked to increased mortality in all age groups, reports a study in The Journal of the American Medical Association.

The first genome-wide association study of antineutrophil cytoplasm antibody (ANCA)–associated vasculitis (AAV) has identified key genetic distinctions between the two major clinical syndromes of the disease. Although the syndromes—granulomatosis with polyangiitis and microscopic polyangiitis—can be differentiated in extreme versions, many patients “fall into the middle in sort of a gray zone where physicians classify them inconsistently,” said Kenneth Smith, MD, PhD, of the University of Cambridge.

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