Findings

/kidneynews/11_2/16/graphic/16f1.jpg

Neighborhood problems and social cohesion are not directly related to decline in kidney function over time—but are still linked to significant differences in chronic kidney disease (CKD) risk factors, according to a study in the American Journal of Kidney Diseases.

Three different measures of adiposity are independent risk factors for decline in glomerular filtration rate (GFR) and death, concludes a meta-analysis in the British Medical Journal.

Plasma endostatin might provide a useful biomarker of the risk of renal dysfunction in patients with type 2 diabetes, according to a study in Kidney International.

A combined regimen of rituximab and cyclophosphamide improves long-term outcomes in patients with renal anti-neutrophil cytoplasm antibody (ANCA)-associated vasculitis (AAV), reports a study in Nephrology Dialysis Transplantation.

The study included 66 patients with AAV and biopsy-confirmed renal involvement. All were treated with a regimen of oral corticosteroids and rituximab plus low-dose pulsed intravenous cyclophosphamide. Maintenance therapy consisted of azathioprine and tapered steroid.

Pediatric organ transplant recipients are at greatly increased risk of hospitalization for vaccine-preventable infections (VPIs), reports a study in JAMA Pediatrics.

The retrospective study included 6980 patients who were less than 18 years old (mean 6.2 years) when they underwent a solid organ transplant from 2004 through 2011. Transplants were performed at 45 not-for-profit US children’s hospitals participating in the Pediatric Health Information System database. There were 2,583 kidney transplant recipients, comprising 37.0% of the sample.

Nearly one-fourth of healthy adults participating in exome sequencing studies have “purportedly pathologic” variants associated with kidney and genitourinary diseases, according to a report in Annals of Internal Medicine.

/kidneynews/11_1/20/graphic/20f1.jpg

For patients with type 2 diabetes, increases in serum creatinine after starting blood pressure–lowering treatment—even greater than 30%—do not necessarily mean that antihypertensive therapy should be decreased, reports a study in Hypertension.

For patients with gout, starting urate-lowering therapy with allopurinol does not appear to lead to an increased risk of developing stage 3 or higher chronic kidney disease (CKD), reports a study in JAMA Internal Medicine.

There is a “dearth of convincing evidence” that lipid-lowering treatment with statin drugs plays any major role in improving outcomes other than cardiovascular disease (CVD), concludes a review and meta-analysis in Annals of Internal Medicine.

Routine catheter replacement does not improve outcomes for hospitalized patients with catheter-associated urinary tract infection (UTI), according to a report in Journal of the American Geriatric Society.

Pages