Coburn Lecture to Cover Endothelial Dysfunction and Vascular Calcification

Orson W. Moe


Orson W. Moe, MD, will present the Jack W. Coburn Endowed Lectureship on Friday during Kidney Week.

His topic will be the roles of fibroblast growth factor-23 (FGF-23) and the transmembrane protein Klotho in endothelial dysfunction and vascular calcification. Klotho mediates the role of FGF-23 in bone-kidney-parathyroid control of phosphate and calcium, and Dr. Moe has published studies showing that Klotho is an early biomarker for chronic kidney disease (CKD) and that Klotho deficiency contributes to soft-tissue calcification in CKD. Dr. Moe’s research includes solute transport and metabolism, kidney stones, acid-base disturbance, and cardiovascular complications of CKD.

Dr. Moe is professor of internal medicine and physiology at the University of Texas Southwestern Medical Center in Dallas. He is the director of the Charles and Jane Pak Center of Mineral Metabolism and Clinical Research and is an active member of the nephrology division at Southwestern. He holds the Charles and Jane Pak Distinguished Chair in Mineral Metabolism Research and the Donald Seldin Professorship in Clinical Investigation.

Dr. Moe has an active practice in patient care and participates in the education of medical students, graduate students, residents, and fellows. He conducts both basic science and patient-oriented research on renal physiology and metabolism as well as epithelial biology. His research strives to cross from the level of the whole patient, to animal and cell culture models, and down to single molecules.

Dr. Moe serves on the editorial boards of the American Journal of Physiology and Journal of the American Society of Nephrology. He is the editor of Current Opinions of Nephrology and Hypertension and editor of the textbook The Kidney by Seldin and Giebisch.

He is a member of the American Society of Clinical Research, American Association of Physicians, American Society of Nephrology, and American Physiologic Society. Dr. Moe received his medical degree from the University of Toronto.


[1] ASN gratefully acknowledges Amgen for support of the Jack W. Coburn Endowed Lectureship.

October-November 2013 (Vol. 5, Number 10 & 11)