Features

Advancement in hypoxia-inducible factor (HIF) stabilizers for treating anemia of chronic kidney disease (CKD) is a prime area to watch in 2020.

On April 15, 2019, the results of the CREDENCE (1) and SONAR (2) trials were published. Both trials showed a 35% reduction in the relative risk of composite renal events in people with type 2 diabetes and kidney disease (DKD).

The Nephrology Match yielded disappointing results again this year.

This is a highly exciting year for nephrology. We will all need not only to watch but to participate in bringing about positive changes in healthcare for preventing and treating kidney diseases, hoping for strong support from the Advancing American Kidney Health initiative. One of the strongest reasons for enthusiasm, and one of the most important aspects, will be advancing clinical trials in nephrology.

Only recently, clonal hematopoiesis of indeterminate potential (CHIP) has been proposed as a novel cardiovascular risk factor linking the innate immune system with aging and vascular inflammation (1, 2).

In people with chronic kidney disease (CKD), the risk of cardiovascular events is independently related to coronary microvascular dysfunction—and not to estimated glomerular filtration rate (eGFR), according to a study by Navkaranbir S. Bajaj and colleagues in a recent issue of Circulation.

The enduring success of solid organ transplantation over the past six decades is also accompanied by the need for immunosuppression regimens with their related systemic toxicity. Transplantation between immunologically diverse individuals led to shortened allograft survival for immunologic reasons (acute and chronic rejection) and nonimmunologic reasons (toxicity of the immunosuppressive medication regimens).

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