M. Amin Arnaout to Receive Homer W. Smith Award

M. Amin Arnaout, MD


Acclaimed physician-scientist M. Amin Arnaout, MD, FASN, will be presented the 2018 Homer W. Smith Award on Friday, October 26. This award recognizes outstanding contributions to understanding how kidneys function in normal and diseased states.

Dr. Arnaout will speak on “Integrins and Kidney Diseases: Basic Concepts and Clinical Implications.”

Dr. Arnaout is professor of medicine at Harvard Medical School, principal investigator at the Harvard Stem Cell Institute, and a physician at Massachusetts General Hospital, where he directs the leukocyte biology/inflammation and the structural biology programs.

He has made seminal contributions to basic and translational medical research for more than three decades through more than 200 publications. His discovery of the cell adhesion receptors known as integrins formed a foundation for development of new anti-inflammatory, anti-thrombosis, and anti-fibrosis drugs for treating common diseases affecting the kidney, heart, and other organs.

Dr. Arnaout also made seminal discoveries in other kidney-related fields. He elucidated the autoantibody nature of C3 nephritic factor, revealed the molecular basis of hemodialysis leukopenia, identified neutrophil proteinase 3 as the target antigen of cytoplasmic antineutrophil cytoplasmic antibodies (c-ANCA), elucidated the role of polycystin 1 in the vasculopathy of autosomal dominant polycystic kidney disease, and developed a microfluidic kidney proximal tubule-on-chip device.

Dr. Arnaout served as chief of nephrology at Massachusetts General from 1998 to 2013. During his tenure, the division became the country’s largest academic center for patient care, physician training, and research in kidney diseases, hypertension, and transplantation. The division’s growth led to a tripling of clinical outpatient visits, a greater than 30% increase in the number of kidney transplants, and a tripling of federal research funding.

He started the hospital’s annual Kidney Care day in 2002, a program that has been adopted worldwide. Dr. Arnaout trained generations of physician-scientists, doctoral students, and clinicians who have assumed leading positions at academic centers and in the biotech industry.

Dr. Arnaout has served the profession in many capacities, including as program chair of the 1998 ASN Renal Week and chair of the ASN Science Committee. He served as a council member of the International Society of Nephrology (ISN) and on study sections at the National Institutes of Health (NIH).

Dr. Arnaout’s many awards include the ASN Presidential Medal for Excellence Award, the NIH Young Investigator Award, ISN Donald Seldin lectureship awards, and the 2017 Kuwait prize in science.

He received his medical degree from the American University of Beirut, followed by an internal medicine residency at its medical center. He completed nephrology and immunology fellowships at Johns Hopkins Hospital, Boston Children’s Hospital, and Harvard Medical School.

October/November 2018 (Vol. 10, Number 10 & 11)