Inflammation and Fibrosis Could Be Keys to Progression of AKI Toward CKD

Manjeri A. Venkatachalam, MBBS


The role of inflammation and fibrosis in the progression of AKI to CKD will be the subject of the Barry M. Brenner, MD, Endowed Lectureship on Friday, Nov. 3.

The speaker will be a scientist who has done extensive research on the topic, Manjeri A. Venkatachalam, MBBS, a professor in the departments of pathology, medicine, and biochemistry at the University of Texas Health Science Center in San Antonio.

Dr. Venkatachalam has a background in both clinical and basic science. He was a house physician in internal medicine for two years prior to five years training in anatomic pathology. He then gained experience as a staff physician practicing diagnostic pathology and renal pathology while conducting basic research.

His research into kidney physiology and pathology has examined proteinuria, glomerulosclerosis, and tubulointerstitial disease. Clinical and epidemiological studies point to the importance of AKI as a harbinger leading to CKD. During the past six years, his research has focused on the pathogenesis of tubulointerstitial pathology in the transition from AKI to CKD. As an early investigator of hemodynamic mechanisms that drive progression of CKD, Dr. Venkatachalam has noted the role that new AKI episodes could play by reducing available renal mass and interacting with CKD pathophysiology to compromise tubule recovery and worsen clinical status.

Dr. Venkatachalam’s laboratory has worked to identify the cellular, biochemical, and signaling basis for defective tubule repair after AKI as well as the role played by failed tubule recovery in the AKI-CKD transition. His most recent research has focused on the role of nuclear and mitochondrial DNA damage in the pathogenesis of tubule atrophy after AKI and the large-scale loss of mitochondria that takes place in the dedifferentiated tubules that become atrophic.

Dr. Venkatachalam serves on the editorial boards of the Journal of the American Society of Nephrology and Kidney International and has been on the boards of Laboratory Investigation and the American Journal of Pathology.

He has served on several National Institutes of Health committees and study sections. For ASN, he has served on the program committee several times and on the acute renal failure advisory group.

He received his medical degree from the Calcutta Medical College and Calcutta University in India, with residencies at Upstate Medical Center in Syracuse, New York, and Boston City Hospital in Massachusetts.

October/November 2017 (Vol. 9, Number 10 & 11)