Glomerular Disease Expert to Give Brenner Lectureship

Lawrence Holzman, MD, will speak on “Defining Structure Function Relationship in Glomerular Failure across Disciplines and Diseases” in the Barry M. Brenner Endowed Lectureship on Thursday, October 25.

Dr. Holzman is C. Mahlon Kline Professor of Medicine and chief of the renal, electrolyte, and hypertension division at the University of Pennsylvania in Philadelphia.

An expert in glomerular disease, he is known for his investigations of podocyte biology, where he has contributed to our understanding of the signaling mechanisms that govern podocyte cytoskeletal architecture in health and disease.

His laboratory has been a leader in characterizing the molecular components of the kidney glomerular filter. He established the first evidence to support the hypothesis that its junctional components participate in regulating podocyte morphology by modulating actin cytoskeletal dynamics. The lab has particularly focused on signaling functions of members of the cell adhesion molecules of the nephrin family. The researchers developed a transgenic mouse strategy for examining the functional biology of proteins and their interactions in the podocyte that is now used internationally.

Recognizing early the need to incorporate precision medicine approaches for glomerular disease patients, he helped found two National Institutes of Health (NIH)-sponsored national longitudinal observational studies of these patients: He teamed with Dr. Matthias Kretzler and Dr. Akinlolu Ojo to create the Nephrotic Syndrome Study Network (NEPTUNE) in 2008. He also helped found Cure Glomerulonephropathy (CureGN), a multicenter five-year cohort study of glomerular disease patients.

He has published more than 100 manuscripts, work made possible by the efforts of his talented students and collaborators and by continuous funding from the NIH and other organizations.

Dr. Holzman is also a dedicated educator and mentor. He served as the nephrology fellowship program director at the University of Michigan and directed its NIH-sponsored T32 training program. He currently directs the T32 program at the University of Pennsylvania.

Dr. Holzman has served on multiple NIH and foundation study sections. He served a term as associate editor of the Journal of Clinical Investigation and worked on the editorial boards of the Journal of the American Society of Nephrology and Kidney International. For ASN, he has served on the Grants Review Committee, on the Policy and Advocacy Committee, and as chair of the Glomerular Disease Advisory Group.

He received his MD from the New Jersey Medical School. He completed his internal medicine residency at the hospital of the Medical College of Pennsylvania and his nephrology fellowship at the University of Michigan Hospital. Over some 20 years, he rose to a full professorship at the University of Michigan Medical School. He left Michigan to join the University of Pennsylvania School of Medicine in 2011.

ASN gratefully acknowledges Monarch Pharmaceuticals for support of the Barry M. Brenner, MD, Endowed Lectureship.

October/November 2018 (Vol. 10, Number 10 & 11)