Blocking TH17 Receptors May Help Fight Type 1 Diabetes

Researchers have found that targeting 2 nuclear receptors that play critical roles in the development of TH17 cells can prevent autoimmunity against pancreatic beta cells in a mouse model of type 1 diabetes. Blocking the receptors also reduced pro-inflammatory cytokine expression, reduced autoantibody production, and increased the frequency of CD4+Foxp3+ T regulatory cells. The Endocrinology findings suggest that the receptors, called retinoic acid receptor-related orphan receptors alpha and gamma t (RORα and RORγt), may be attractive targets for treating type 1 diabetes.

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Researchers have found that targeting 2 nuclear receptors that play critical roles in the development of TH17 cells can prevent autoimmunity against pancreatic beta cells in a mouse model of type 1 diabetes. Blocking the receptors also reduced pro-inflammatory cytokine expression, reduced autoantibody production, and increased the frequency of CD4+Foxp3+ T regulatory cells. The Endocrinology findings suggest that the receptors, called retinoic acid receptor-related orphan receptors alpha and gamma t (RORα and RORγt), may be attractive targets for treating type 1 diabetes.

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