Sulfonylurea May Increase Testosterone in Men with Type 2 Diabetes

Compared with 15 healthy controls, 15 men with type 2 diabetes from a clinical trial of glimepiride had reduced total testosterone levels and a lower testosterone secretion index. However, after 16 weeks of treatment there were significant increases in total testosterone levels and testosterone secretion index values compared with baseline, and significant improvements in blood glucose and lipid profile levels, with no differences in body weight and waist circumference compared with baseline values. There were also no considerable changes in luteinizing hormone, follicle stimulating hormone, and sex hormone binding globulin levels, according to the Journal of Diabetes Investigation study.

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Compared with 15 healthy controls, 15 men with type 2 diabetes from a clinical trial of glimepiride had reduced total testosterone levels and a lower testosterone secretion index. However, after 16 weeks of treatment there were significant increases in total testosterone levels and testosterone secretion index values compared with baseline, and significant improvements in blood glucose and lipid profile levels, with no differences in body weight and waist circumference compared with baseline values. There were also no considerable changes in luteinizing hormone, follicle stimulating hormone, and sex hormone binding globulin levels, according to the Journal of Diabetes Investigation study.

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