Low Hemoglobin Levels Linked with Poor Outcomes in Patients with CKD

Among 3405 patients with CKD, a hemoglobin level <10 g/dL was linked with an 84% increased risk of a composite endpoint of all-cause mortality, cerebrovascular events, and myocardial infarction compared with a reference level of ≥10 or higher but <11. In the Nephron Clinical Practice analysis, which included 9 prospective randomized controlled trials, patients whose hemoglobin level decreased by >1 g/dL from their target value (10 to 13 g/dL) had a 2.6 times, 2.9 times, and 2.6 times increased risk of the composite endpoint, all-cause mortality, and cerebrovascular events, respectively, compared with patients who maintained their hemoglobin level.

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Among 3405 patients with CKD, a hemoglobin level <10 g/dL was linked with an 84% increased risk of a composite endpoint of all-cause mortality, cerebrovascular events, and myocardial infarction compared with a reference level of ≥10 or higher but <11. In the Nephron Clinical Practice analysis, which included 9 prospective randomized controlled trials, patients whose hemoglobin level decreased by >1 g/dL from their target value (10 to 13 g/dL) had a 2.6 times, 2.9 times, and 2.6 times increased risk of the composite endpoint, all-cause mortality, and cerebrovascular events, respectively, compared with patients who maintained their hemoglobin level.

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