Certain Risk Factors Link Low Birthweight with Diabetes

In a recent study, women with a low birthweight (<6 pounds) were 2 times more likely to develop type 2 diabetes than women with a birthweight of 8 to 10 pounds. Insulin resistance contributed most strongly, accounting for 47% of the effect. High levels of E-selectin (a marker of problems with blood vessel lining) accounted for 25%, low levels of sex-hormone binding globulin contributed 24%, and high systolic blood pressure accounted for 8%. The Diabetologia findings pertain to 1259 incident type 2 diabetes cases and 1790 controls in the Women’s Health Initiative-Observational Study.

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In a recent study, women with a low birthweight (<6 pounds) were 2 times more likely to develop type 2 diabetes than women with a birthweight of 8 to 10 pounds. Insulin resistance contributed most strongly, accounting for 47% of the effect. High levels of E-selectin (a marker of problems with blood vessel lining) accounted for 25%, low levels of sex-hormone binding globulin contributed 24%, and high systolic blood pressure accounted for 8%. The Diabetologia findings pertain to 1259 incident type 2 diabetes cases and 1790 controls in the Women’s Health Initiative-Observational Study.

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