New Insights into Role of APOL1 Gene Variants and FSGS

Among 94 patients with focal segmental glomerulosclerosis (FSGS), those with 2 APOL1 variants tended to have more advanced disease at diagnosis, which fits with observations that this genetic form of FSGS progresses rapidly. Patients with the variants responded to cyclosporine and mycophenolate mofetil just as well as other patients, but they progressed more rapidly to kidney failure. Among self-identified African American participants in the JASN study, 72% had APOL1 risk variants as did 2 individuals of Hispanic descent. The variants were also present in 2 individuals who self-identified as white or European-American, which has not been reported before.

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Among 94 patients with focal segmental glomerulosclerosis (FSGS), those with 2 APOL1 variants tended to have more advanced disease at diagnosis, which fits with observations that this genetic form of FSGS progresses rapidly. Patients with the variants responded to cyclosporine and mycophenolate mofetil just as well as other patients, but they progressed more rapidly to kidney failure. Among self-identified African American participants in the JASN study, 72% had APOL1 risk variants as did 2 individuals of Hispanic descent. The variants were also present in 2 individuals who self-identified as white or European-American, which has not been reported before.

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