Project Title: Hepcidin, Dysregulated Iron Homeostasis, and Anemia in Human Acute Kidney Injury
How would you sum up your research in one sentence?
I conduct patient-oriented research in acute kidney injury, with an emphasis on identifying novel pathways and therapeutic targets
Provide a brief overview of the research you will conduct with help from the grant.
Using samples from the ATN trial, I will explore whether plasma hepcidin levels are elevated in critically ill patients with established acute kidney injury (AKI), and whether this elevation contributes to AKI-associated anemia and other adverse outcomes. Additionally, using samples from an ongoing, randomized, double-blind, placebo-controlled trial of activated vitamin D metabolites in critically ill patients, I will explore whether elevated hepcidin levels in critical illness can be lowered by administration vitamin D metabolites.
What inspired you to focus your research in this area?
Anemia is a nearly universal complication of advanced chronic kidney disease and is a major area of investigation. Anemia as a complication of acute kidney injury, on the other hand, has received much less attention, yet is likely contributes to adverse outcomes in this setting as well. I believe that elevated levels of hepcidin may be a major contributor to anemia in patients with AKI.
What impact do you hope your research will have on patients?
I hope that this research will help elucidate the mechanisms of anemia in patients with AKI and thereby provide a potential therapeutic target for future interventional studies to improve outcomes in patients with AKI.
What are your short- and long-term career goals?
I hope that by the end of the grant period I will have answered the questions I proposed in relation to AKI-associated anemia. Five-to-ten years from now, I hope to have conducted a randomized controlled trial in this area to assess whether targeting anemia in patients with AKI could be a strategy to improve outcomes in this group of patients.
What has surprised you most about your career?
How collaborative most people in the research community have been.
Describe the importance of having grant funding available through the ASN Foundation.
This ASN Foundation grant will be critical to my success in becoming an independent investigator and in establishing a new area of investigation within the field of AKI.
What advice would you give to others to encourage them to apply for this grant funding?
It’s a wonderful grant opportunity, especially in the last few years of a K-award during which time additional funding is needed to investigate new areas.
Something you may not know about me is…
I’m a NY rangers fan.
In my free time I like to…
Spend time with my wife and daughter, work out, play tennis, ski, and travel