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Mark A. Perazella and Mitchell H. Rosner

Over the past 10 to 20 years, there has been a revolution in the care of patients with cancer. In addition to classic chemotherapy agents, anti-cancer agents now include targeted therapies and immunotherapies, which harness the power of the immune system. These new therapies have transformed cancer into a chronic disease for many patients. Importantly, acute and chronic kidney diseases, electrolyte and acid-base disorders, and hypertension have become highly prevalent complications in this group of patients. This is particularly true for those with liver cancer, multiple myeloma, renal cell carcinoma, leukemias and lymphomas, and cancer patients treated with potentially nephrotoxic

Evan Xu and Ziyad Al-Aly

Beyond its acute effects, it is now compellingly clear that infection with SARS-CoV-2 leads to serious long-term health consequences—referred to as long COVID. Of particular concern is the increased risk of cardiometabolic disease, including kidney diseases, diabetes, and cardiovascular disease (Figure 1).

Cardiometabolic consequences of long COVID

In the first large-scale, high-dimensional characterization of the post-acute sequelae of COVID-19, we showed that people who survive the acute phase of COVID-19 have increased risk of post-acute sequelae involving pulmonary and a wide array of extrapulmonary disorders (1).

Further work from our team revealed that people

This is an abridged version of ASN's Statement on Climate Change, which can be viewed in its entirety online at

The American Society of Nephrology (ASN) calls on kidney health professionals to take action to address the impact of climate change on the 850 million people—including more than 37 million Americans—living with kidney diseases across the world who are uniquely vulnerable to the effects of climate change.

Climate change—defined by the United Nations Framework Convention on Climate Change as “a change of climate which is attributed directly or indirectly to human activity that alters the

Drinking at least two cups of coffee per day has a protective effect against acute kidney injury (AKI), reports a study in Kidney International Reports.

The analysis included 14,207 adults, aged 45 to 64 years, from the population-based Atherosclerosis Risk in Communities (ARIC) study. Coffee consumption was assessed at a single study visit using a semiquantitative food-frequency questionnaire and was evaluated for association with incident AKI.

Of the participants, 27% never drank coffee, 14% drank less than one cup per day, 19% drank one cup per day, 23% drank two or three cups per day, and 17% drank

Adam Weinstein and Eileen Brewer

Health care providers eagerly anticipate the Centers for Medicare & Medicaid Services (CMS) updates to the physician fee schedule (PFS) in the Federal Register each fall. The PFS, which assigns relative value units (RVUs) to Current Procedural Terminology (CPT) codes, is CMS's price list for physician services. The published CPT values result from thousands of hours of work by specialty society representatives (called advisors) and the 32 members of the American Medical Association (AMA)/Specialty Society Relative Value Scale Update Committee (RUC) (1).

Per AMA bylaws, specialty societies that meet requirements for representation in the AMA House

Detective Nephron, world-renowned for his expert analytic skills, trains budding physician-detectives in the diagnosis and treatment of kidney diseases. Mackenzie Ula Densa, a budding nephrologist, plans to present a new case to the master consultant.

Nephron It's been a while, Mac. What do you have for me?

Mac I have a 67-year-old man with a serum sodium (Na) of 120 mEq/L.

Nephron (excited) Whoa! Finally…electrolytes stuff!

Mac Trust me, you are going to love this one. You are like a child when it comes to hyponatremia.

Nephron Did you know that hyponatremia is

Recent research suggests a potential expanded role for monitoring of donor-derived cell-free DNA (dd-cfDNA) in the early identification of graft injury after kidney transplantation.

In the Assessing Donor-Derived Cell-Free DNA Monitoring Insights of Kidney Allografts with Longitudinal Surveillance (ADMIRAL) study, published in Kidney International, 1092 kidney transplant recipients were monitored for dd-cfDNA for 3 years after transplantation. The researchers used a targeted sequencing assay that quantified dd-cfDNA using highly polymorphic single nucleotide polymorphisms without the need for separate donor or recipient genotyping. The findings of 5873 dd-cfDNA measurements were analyzed for association with histologic evidence of allograft rejection.

Charuhas V. Thakar
The effort conundrum

Let me dive right in! A traditional business plan equates one full-time equivalent (FTE) to 8 out of 10 half-day sessions of direct clinical work, which expects the physician to complete an average of 12 patient visits in a 4-hour clinic session (a typical visit is 15 minutes for follow-up and 30 minutes for a new patient). There are three recipients of the deliverables during a clinic visit: 1) the recipient of the clinical care is the patient; 2) the recipient of the professional billing is the practice plan; and 3) the recipient of most of the

Bridget M. Kuehn

As a family physician and diabetes team lead in Juneau working for the Southeast Alaska Regional Health Consortium, Mary Owen, MD, could audit the care received by all of the diabetes patients served by her tribal clinic. The Special Diabetes Program for Indians (SDPI) funded this population-based approach through the Indian Health Service (IHS), which contracted with the clinic.

The audits allowed Owen, now director of the Center of American Indian and Minority Health at the University of Minnesota Medical School, to assess blood pressure and blood sugar control among patients and to gauge how many patients were receiving guideline-directed

The American Kidney Fund (AKF) has awarded its 2022 Clinical Scientist in Nephrology Program fellowships to two deserving researchers: Jillian Caldwell, DO, a nephrology fellow with Stanford University School of Medicine, and Janewit Wongboonsin, MD, MS, a clinical and research fellow with the Brigham and Women's Hospital (BWH)-Massachusetts General Hospital (MGH) Renal Fellowship Program, conducting his postdoctoral research at Boston Children's Hospital (BCH). Kidney News is honored to present an interview with these awardees.

Jillian Caldwell, DO

Fellowship project: How immunologic matching in kidney transplantation can affect equitable access to organs

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