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Eryn E. Dixon

The advancements of single-cell and nucleus RNA sequencing (sc/snRNAseq) have shifted our approach to defining cell types and states relevant to human health. These technologies have provided detailed insight into the transcriptome (all of the expressed messenger RNA [mRNA] of a single cell, tissue, or sample) of a single cell. However, this process, requiring dissociation of tissue to the level of the single cell or nucleus, obscures the structural context of each cell within the tissue. Therefore, sc/snRNAseq studies have been limited by their inability to capture data essential to understanding these cellular microenvironments (surrounding cells, extracellular matrix, and signaling

Seth J. Karp

The old tongue-in-cheek maxim that xenotransplantation is, and always will be, the future of transplantation is under withering attack. Three reports within the past few months—one published in a scientific journal (1) and two in the lay press—suggest xenotransplantation success may be at hand. First, a little history.

Xenotransplantation promises an unlimited supply of organs. Conceptually straightforward, the details turn out to be critically important. First attempts at xenotransplantation using pigs were unsuccessful due to, among other issues, the Galα1,3Gal (Gal) epitope on the vascular epithelium. These epitopes induced refractory rejection, leading to organ loss in transplant models.

Congressional support is paramount for increasing investment in kidney health research at NIDDK, more funding for KidneyX to accelerate innovation, and protections for living organ donors.

Using data from a health center during a COVID-19 surge, researchers consider the impact and potential of palliative care for patients with acute kidney injury.  

Congress is staring down a significant number of legislative backlogs as it begins the 2022 calendar year. Congress must still finalize fiscal year (FY) 2022 appropriations before FY 2023 appropriations negotiations can commence, confirm the heads of both the US Food and Drug Administration and National Institutes of Health amid the global COVID-19 pandemic, and confirm a Supreme Court justice to replace retiring Justice Breyer, all with mid-term elections fast approaching this fall. But, there is cause for genuine optimism among the kidney community, as improving kidney health through transformative regulatory and legislative action continues to receive robust bipartisan support

Kiri Bagley and Brianna Borsheim

Twenty percent of Americans live in rural areas. Many face health disparities caused by geographic isolation, transportation limitations, and a lack of access to local specialty health care (1, 2). Americans living in rural areas also are more likely to be uninsured, to have lower rates of access to preventive health services, and to engage in unhealthy behaviors (such as tobacco use) (25). They also have greater incidence rates of potentially preventable diseases, including heart disease and stroke, and higher mortality rates than their urban counterparts (2, 4,

Dinushika Mohottige and Mitchell R. Lunn

Lesbian, gay, bisexual, transgender, queer or questioning, and/or other sexual and gender minority (SGM) individuals (LGBTQ+) represent a diverse range of people who experience disparities in health outcomes and other health-promoting resources and opportunities and are served by kidney care professionals (13).

Although there have been advances in civil rights legislation, including same-sex marriage equality aimed to equalize some sociopolitical opportunities, there are innumerable persistent social, economic, legal, health, and health care-related disparities facing SGM individuals (2, 4). These challenges are exemplified by a patchwork of non-discrimination policies across the United States

Andrea Kattah

The challenges for women in medicine are well documented: Women get paid less than men (1, 2). Women are under-represented in leadership positions at academic institutions (3, 4). Women bear more of the burden at home in dual professional households (5). The headlines are so familiar that it can be difficult for one to muster outrage. Although there are increasing victories in the struggle for equality, such as the inclusion of female voices on academic panels, systemic changes are needed to level what has historically been an uneven playing field.

It's March, spring is in the air, and periodic bracket fever has caught up with the nephrology community for the 10th year in a row! What is NephMadness, you may ask? NephMadness is a medical education event held in your practice, your division, and on social media to celebrate all things kidney.

NephMadness is a single-elimination tournament consisting of 32 nephrology concepts, divided into 8 regions, representing the most exciting topics in nephrology. The purpose of the game is to discuss and debate each of these concepts during the month of March. Throw a NephMadness party for your group, and

Tod Ibrahim

In 1960, my father immigrated to the United States to avoid religious persecution, experienced racism in Ohio, overstayed his student visa, and was considered “illegal.” My mother—whose family has deep, often racist, roots in the United States—eloped with my father, helped him become a US citizen, experienced sexism (especially in the workplace), worked for two female members of Congress, and volunteered as a counselor during the AIDS crisis.

Their individual and shared experiences shape my commitment to diversity, equity, inclusion, and justice. The American Society of Nephrology (ASN) was a pacesetter—and is now an advocate—in this arena because its members,