The average cost of procuring a deceased-donor kidney is $36,000, but the cost varies substantially between different organ procurement organizations (OPOs), concludes a study in the American Journal of Transplantation.
The researchers analyzed annual cost reports from 51 of 58 OPOs in the United States from 2013 to 2017. Data analysis focused on variations in kidney procurement costs, including differences in costs by OPO size, based on annual number of kidneys procured. The analysis also considered costs associated with acquisition of viable (transplanted) versus nonviable (discarded) kidneys and other OPO outcomes.
Among patients with CKD, those taking opioids have a higher rate of adverse outcomes than those taking nonsteroidal anti-inflammatory drugs (NSAIDs), reports a study in the American Journal of Kidney Diseases.
Using data from the Chronic Renal Insufficiency Cohort (CRIC), the researchers analyzed the relationship between analgesic use and clinical outcomes in patients with CKD. The analysis included 3939 CRIC participants with CKD not requiring kidney replacement therapy (KRT). The patients reported 30-day analgesic use at annual study visits. At baseline, 9.9% of patients were using opioids and 15.5% were taking NSAIDs.
Four years ago, I interviewed you for Kidney News about your poster at ASN Kidney Week. You were a high school junior at the time. Can you briefly tell us how your research has developed since then?
I will always be grateful to ASN for giving me the opportunity to present a poster at Kidney Week 2016. This one presentation provided a jump start to my career.
In my research study, I quantified soda acidity/phosphorus levels and conducted a soda-consumption survey. As is known, the potential health implications associated with soda overconsumption include heart/bone disease and calciphylaxis.
Given before coronary angiography in high-risk patients, recombinant human C1-esterase-inhibitor (rhC1INH) reduces biomarkers for contrast-induced kidney injury, reports a trial in JACC: Cardiovscular Interventions.
The Prophylactic RhC1-inhibitor to Prevent Contrast-induced Nephropathy (PROTECT) trial included 77 high-risk patients scheduled for elective coronary angiography. All had an eGFR of ≤50 mL/min per 1.73 m2 plus one additional risk factor (diabetes, age ≥75, anemia, congestive heart failure, or history of pulmonary edema). The patients were 54 men and 23 women, mean age 77 years and mean eGFR 40 mL/min per 1.73 m2.
Higher-volume transplantation centers achieve better outcomes in children undergoing kidney transplantation, according to a study in Kidney Medicine.
The case-cohort study included data on 3762 kidney transplants in patients <18 years between 2010 and 2015, drawn from the Scientific Registry of Transplant Recipients. Procedures were performed at 115 centers, which were classified as low-volume (fewer than four transplantations per year), intermediate-volume (four to eight per year), and high-volume (more than eight per year). The 3-year graft survival was compared among these volume groups, with adjustment for covariates.
The three groups of recipients were similar in terms of sex,
The first 72 hours after diagnosis of acute kidney injury (AKI) have a major impact on the long-term risk of kidney-specific outcomes, according to an analysis of prospective cohort data reported in JAMA Network Open.
The study included 1538 hospitalized patients from the prospective multicenter Assessment, Serial Evaluation, and Subsequent Sequelae of Acute Kidney Injury (ASSESS-AKI) study: 769 patients with AKI and 769 without. Participants were enrolled 3 months after hospital discharge between 2009 and 2015, with follow-up to 2018. The two groups were matched for demographic characteristics, hospital, comorbidity, and preadmission estimated glomerular filtration rate (eGFR).
A video played at Alabama Department of Motorized Vehicles (DMV) facilities—specifically targeting African Americans—resulted in a modest but significant increase in organ donor registrations, reports a study in Transplantation.
The 10-minute video was created by a professional film company experienced in producing motivational “call to action” videos. The video built on previous research with African American DMV patrons and was developed with input from members of the community. Topics included medical mistrust, the need for donor organs, and stories shared by organ donor and recipient families. The video also featured brief promotional clips by well-known local figures, such
Beyond the first year, kidney transplant recipients (KTRs) have an excess risk of mortality, compared to matched chronic kidney disease (CKD) patients who do not undergo kidney transplantation, reports a preliminary study in Nephrology Dialysis Transplantation.
The analysis included patients from two French multicenter prospective cohorts: 340 KTRs and 605 nontransplant CKD patients. The groups were matched on a propensity score incorporating six outcome-dependent variables assessed at cohort enrollment, including estimated glomerular filtration rate (eGFR). Mean eGFR at inclusion was 42 and 41 mL/min/1.73 m2, respectively. All-cause mortality was compared between groups, with cardiovascular events as
What does it take for a man to refuse lifesaving dialysis? Despite thorough counseling, our team stood still as our patient continued to refuse hemodialysis for his kidney failure. Admitted because of his severely elevated potassium levels, he understood his imminent risk for sudden cardiac arrest. Yet, as the buildup of toxins in his bloodstream worsened his lethargic and nauseated state, he remained adamant that his family lacked the means to continue with the emergency dialysis he needed to survive.
For our patients of undocumented status, the tragic lack of access to
Among patients with type 2 diabetes undergoing bariatric surgery, adolescents have earlier resolution of elevated urinary albumin to creatinine ratio (UACR), compared to adults, reports a study in Kidney International.
The researchers analyzed 161 adolescents with severe obesity who underwent Roux-en-Y gastric bypass surgery. For comparison, they looked at a group of 396 adults undergoing gastric bypass—all with a reported history of obesity at age 18 or younger. Before gastric bypass, type 2 diabetes was present in 14% of the adolescents and 31% of the adults. For patients with preoperative type 2 diabetes, the adolescents and adults were