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High dietary phosphate levels are known to be harmful for patients with advanced kidney disease. Now an abstract presented at ASN Kidney Week 2017 suggests that high phosphate diets also may have detrimental effects on the cardiovascular health of healthy people.

In patients with advanced kidney disease there is evidence that a high-phosphate diet is associated with worse cardiovascular disease, said Kevin J. Martin, MD, a professor of internal medicine and director of the division of nephrology at St. Louis University, who was not involved in the study. In fact, patients are often urged to limit phosphorous in their diets,

Elevated nighttime blood pressure may be a warning sign that a child with kidney disease is at risk of faster progression, according to an abstract presented at Kidney Week.

Hypertension is a risk factor for kidney disease, and is linked to faster progression. Typically, physicians monitor blood pressure with readings during clinic visits. However, use of 24-hour ambulatory blood pressure monitoring is increasing, and emerging data suggest that high nighttime blood pressure may be a particularly important risk factor in kidney disease. For example, a recent study in adults with kidney disease suggested that elevated nighttime blood pressure may lead

Bridget M. Kuehn

Starting dialysis with a fistula has been shown to improve patient outcomes, but the challenge of getting a surgically created fistula in time to start dialysis is often hard to overcome. But trial results presented at Kidney Week suggest a minimally invasive technique for creating a fistula may one day allow interventional nephrologists to quickly and safely create fistulas.

The study was one of several late-breaking studies presented at the meeting that suggested innovative techniques, trial designs, and treatments might yield better results for patients with kidney disease and those at risk. Among them were a pragmatic trial examining the

Bridget M. Kuehn

Greater reductions of mean arterial pressure were linked to reduced kidney function, according to an analysis of data from the SPRINT trial presented at Kidney Week.

The SPRINT trial demonstrated that tight blood pressure control—with a systolic target of less than 120 mm Hg—reduced the risk of death among nondiabetic patients at high risk of a cardiovascular event. But that tight control was associated with reduced kidney function.

To better understand the kidney-associated effects of tight blood pressure control, Rita Magriço, MD, of the Hospital Garcia de Orta in Portugal, and her colleagues took a second look at the SPRINT

Bridget M. Kuehn

Eating a lower acid diet—typically lots of fruits and vegetables—may help boost exercise capacity, particularly for older patients, according to an abstract presented at Kidney Week.

Acid-producing diets, such as those rich in animal proteins, can exacerbate chronic kidney disease—so nephrologists often prescribe a low acid diet or bicarbonate supplements to balance a patient’s acid load. High acid diets may also have ill effects on otherwise healthy individuals, particularly those who are experiencing age-related renal decline.

Now, Enni-Maria Hietavala, MS, a PhD student in the laboratory of Antti Mero at the University of Jyväskylä in Finland, shows that eating a

Using proton pump inhibitors (PPIs) increases the risk of developing chronic kidney disease (CKD) or kidney failure by 33%, according to a meta analysis presented at Kidney Week.

PPIs are one of the most commonly prescribed medications worldwide. They are used to treat gastroesophageal reflux disease (GERD). But a growing number of studies have linked them to serious adverse effects including kidney disease, fractures, Clostridium difficile infections, and vitamin deficiencies (Wilhelm SM, et al. Expert Rev Clin Pharmacol 2013; 6:443–451).

To assess the potential kidney risks, Charat Thongprayoon, MD, of the Bassett Medical Center in Cooperstown,

A plant-based protein appears to reduce heart damage in a mouse model of chronic kidney disease (CKD), according to a study presented at Kidney Week.

Cardiovascular disease is a common complication in patients with CKD. Ryohei Kaseda, MD, PhD, of the division of clinical nephrology and rheumatology at Niigata University School of Medical and Dental Sciences in Japan, and colleagues have previously shown that high-density lipoprotein (HDL) cholesterol may lose its beneficial effects in the setting of kidney dysfunction (Yamamoto S, et al. J Am Coll Cardiol 2012; 23:2372–2379). In their study, they looked at whether replacing animal

Eleanor D. Lederer and Crystal Gadegbeku

Eleanor D. Lederer, MD, FASN

Crystal Gadegbeku, MD

The Department of Veterans Affairs (VA) and ASN co-sponsored the Kidney Innovation Summit on February 9–10, 2017, to advance innovation in kidney disease care through intense knowledge sharing, discussion, and networking. ASN Policy and Communications Specialist David White caught up with ASN President Eleanor D. Lederer, MD, FASN, and Crystal Gadegbeku, MD, Chair of the Policy and Advocacy Committee of ASN, to discuss their thoughts on advancing innovation in kidney disease care.

DAVID WHITE

What can you tell us about the summit?

DR. GADEGBEKU

The summit provided a sort of meeting of

Eleanor Lederer
TOD IBRAHIM

I’m curious, when did you decide to become a nephrologist?

ELEANOR LEDERER

It wasn’t until my third year of residency. Actually, I was interviewing for positions in internal medicine private practice in Houston, which is where I trained, at Baylor College of Medicine. I had one month during which I was rounding on the general medicine service at our county hospital. My attending was the chief of the renal division, Wadi Suki. It was one of those months that it seemed every other patient was a kidney patient. We had cases of malignant hypertension, flagrant lupus nephritis, a

Leslie Trigg
What spurred your interest in Outset Medical?

Most of my medical device career has been in spent in areas of healthcare that have experienced rapid, technology-driven change. In cardiology, for example, it’s not unusual to see several groundbreaking new devices enter the market in the same year. What hit me right away about dialysis was the inverse. The paucity of new technologies was striking. Being new to it, I thought, “Well, is new technology needed? Maybe there are no unmet needs that can be solved by technology.” Those questions were quickly answered by learning more about the clear need for