Chicago—Stem cells from patients with polycystic kidney disease have been coaxed into growing into kidney-like structures, which may aid researchers studying the disease, according to a study presented at Kidney Week 2016.
Ryuji Morizane, MD, PhD, an instructor and scientist in the Brigham and Women’s Hospital Renal Division in Boston, and his colleagues presented data on how they grew the kidney-like structures, called kidney organoids. They also described the features of the kidney organoids and the disease features they recreate.
Improvements in cell culturing technology have allowed scientists to coax stem cells into growing into organoids that recapitulate many of
Chicago—Too little and poor quality sleep are associated with a greater risk of kidney failure, according to results from the Chronic Renal Insufficiency Cohort Study (CRIC) presented at Kidney Week 2016.
While sleep disorders are common in patients with chronic kidney disease (CKD), how poor sleep may affect disease progression is not clear, according to the study’s lead author Ana C. Ricardo, MD, MPH, an assistant professor in the division of nephrology at the University of Illinois College of Medicine at Chicago.
So Ricardo and her colleagues conducted a prospective study of 432 adults enrolled in the CRIC study at
Smoking may partly counteract the benefits of treatment with angiotensin converting enzyme inhibitors (ACE inhibitors) for patients with chronic kidney disease (CKD), according to a study presented at Kidney Week 2016.
Smoking has been linked to worsening kidney decline, but the exact mechanisms are unclear, according to lead author Bethany Roehm, MD, of Tufts Medical Center in Boston.
“The importance of smoking as a renal risk factor is highlighted by the fact that its negative effects have been shown in subjects of the general population and in patients with primary or secondary renal disease,” said Stephan R. Orth, MD, PhD,
Use of palliative care among patients with end stage renal disease (ESRD) has increased steadily since 2004, but use among minority patients lags behind whites, according to a study presented at Kidney Week 2016.
Palliative care, which focuses on comfort measures and may include discontinuing dialysis, may ease the burden for patients with ESRD who are nearing the end of life. To help ensure that patients are advised about the option of palliative care, the Centers for Medicare & Medicaid Services included voluntary end-of-life counseling in the 2016 physician fee schedule, wrote lead author Haytham Alkhaimy, MD, of Augusta (Georgia)
Patients who need dialysis for the treatment of ESRD have a high burden of disease because they have numerous coexisting illnesses (such as diabetes and congestive heart failure), high health care utilization with frequent hospitalizations and high rates of readmission, and a very high daily pill burden. The dialysis regimen adds further to this burden, because patients have to make significant changes in their day-to-day lives, including in their diets, to accommodate the treatment schedules and minimize risks to their health. Patients have further challenges in coping with the numerous demands imposed by a diagnosis of ESRD if they also
What do you mean my kidneys are failing?” “What is dialysis?” “Am I going to die?” “This can’t be happening to me.” “What about my family?” “I am afraid….” The diagnosis of kidney disease is a life-changing event for individuals and their families. Their entire world has just changed. They have lost their safe and secure view of their own sense of good health and well-being. Their sense of the future is not as certain. They are in crisis and grief. Crisis can be viewed as a critical event that requires people to develop new ways and acquire new skills
Having recently experienced an excellent meeting on mental health, chronic kidney disease (CKD), and ESRD, I wanted to offer some thoughts about the extraordinary role that psychology and people play in the course of this illness and its treatment. I commend the Rogosin Institute for convening a marvelous group of leaders from various parts of the country to deliberate on these issues.
What does one learn from such a roundtable? First and foremost, that kidney disease has a potential for dramatically disturbing a person’s sense of well-being. Many people with serious kidney disease are not aware that they have it.
Major depression is a complicating comorbid diagnosis in a variety of chronic medical conditions, but may be a particular diagnostic and treatment challenge to the patient with end stage renal disease (ESRD). New Medicare guidelines mandate that dialysis providers must screen for depression, and soon they will be required to document a treatment plan. This new requirement is forcing kidney care providers to seriously consider the best approaches to accurately diagnose and treat patients on dialysis once they have been identified as having depression. There are a variety of diagnostic tools used to screen for depression, each with their own
I am not sure there is a good way to start dialysis, but I am certain that crashing into it is not the way to go.
These impressions had nothing to do with the quality of care I received but reveal how overwhelming and impersonal the experience was, especially considering I was not functioning at top level when the situation began.
In one morning, I went from being on vacation away from home, thinking I had the flu while recovering from bronchitis and altitude sickness, to being admitted to the intensive care unit (ICU) with kidney failure.
Approximately one in five women and one in 10 men will suffer from depression over the course of their lives (1). Chronic illness generally confers an even greater risk for depression. Patients with chronic kidney disease (CKD) and in particular, those who are on hemodialysis (HD) are at a relatively high risk for depression. It is difficult to determine the exact rate of major depressive disorder (MDD) in patients with CKD because the somatic symptoms of depression are similar to the symptoms of uremia (e.g., decreases in appetite, energy, sexual interest, and sleep). Aches and pains are common