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This article has been updated to include the following Correction:
The February
In reality, nephrology has access to the RUC,
“There's something special about chlorthalidone.”
–Rajiv Agarwal, MD, as heard on “Freely Filtered”
The nephrology community was abuzz at ASN Kidney Week 2021 as Rajiv Agarwal presented the results of the Chlorthalidone in Chronic Kidney Disease (CLICK) trial, with simultaneous publication in
In an attempt to refute the dogma that thiazide-like diuretics lose effectiveness at low estimated glomerular filtration rate (eGFR)
For patients with advanced chronic kidney disease (CKD), early dialysis initiation—at an estimated glomerular filtration rate (eGFR) of 15–16 mL/min/1.73 m2—leads to modest reductions in mortality and cardiovascular events, reports a study in
“However, to reach the maximum survival benefit, patients would need to start dialysis up to 4 years earlier,” comments lead author Edouard Fu, PhD, a research fellow at the Division of Pharmacoepidemiology and Pharmacoeconomics at Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts.
The conclusions are consistent with the sole previous randomized trial of dialysis initiation times—and support
Hippocrates. Engraving based on drawing by Peter Paul Rubens. National Library of Medicine, Bethesda, MD (CC by 4.0).
Portrait of Richard Bright from Thomas Joseph Pettigrew, Medical Portrait Gallery, vol. 2 (1838).
Nephrology is a relatively young specialty. It emerged in the second half of the 20th century, with the rise of kidney biopsy, dialysis, and transplantation. Although kidneys have been studied since antiquity, stones and obstruction were a dominant focus. Urology books from 1739 mention the only treatment of anuria as bladder catheterization
As a specialty, nephrology is heavily dependent on international medical graduates (IMGs). According to the Association of American Medical Colleges (AAMC)
Methotrexate (MTX) has been used for treatment of connective tissue disorders, including rheumatoid arthritis. In much higher doses, MTX is used for various hematologic and oncologic disorders
Emoji are text-embedded pictograms used to communicate and provide context in written electronic messages. Billions of emoji are sent worldwide every day
A nationwide data analysis confirms that SARS-CoV-2 antibody responses to vaccination decrease rapidly in dialysis patients, leaving them at risk of breakthrough infection, reports
The researchers analyzed real-world data on 4791 patients receiving care in a large US network of dialysis facilities. Residual plasma from routine monthly tests performed at a central laboratory was used to measure qualitative and quantitative antibodies to the SARS-CoV-2 receptor-binding domain (RBD). The analysis began in January 2021, before COVID-19 vaccines were widely available. By mid-September 2021, 2563 patients were fully vaccinated.
Trends in antibody levels were assessed, including the
Immunoglobulin A nephropathy (IgAN) is the most common glomerular disease worldwide
