Transplantation & Immunology

Communities Weekly Rewind: ABO incompatible kidney transplant; role and significance of IgM antibody titers

Query
Is it safe to proceed with this transplant without lowering the anti-B IgM titers?  Is this risking early post-transplant antibody mediated rejection?

Communities Weekly Rewind: Hope and Innovation in Nephrology

Months of efforts by ASN staff culminated on April 26, 2018, when ASN signed a Memorandum of Understanding with the Department of Health and Human Services to establish the Kidney Innovation Accelerator, KidneyX.

Newly Launched KidneyX Aims to Accelerate the Commercialization of Innovative Therapies in Kidney Care

ASN and the U.S. Department of Health and Human Services (HHS) have sent a clear signal in their desire to have new therapies in the kidney space through the signing of a Memorandum of Understanding establishing the Kidney Innovation Accelerator (KidneyX), a collaborative environment in which a community of researchers, innovators, and investors can participate.

ASN, along with 36 kidney organizations, signed letter to Senate Appropriations for additional kidney research funding at NIH

On Monday, April 23, the American Society of Nephrology and a record-setting coalition of 36 other organizations in the kidney community, authored a letter to the leadership of the House and Senate Appropriations Subcommittees that appropriate funds for the National Institutes of Health (NIH).

Communities Weekly Rewind: Liver transplant alone vs. simultaneous liver-kidney transplant

Query
Should this patient receive a liver transplant alone (LTA) or simultaneous liver and kidney transplant (SLK).

Study reveals US transplant recipient health outcomes advantage drops after first year

“While kidney transplant recipients in the United States initially have better outcomes compared to patients in other countries, registry data show that advantage disappears after the first year, according to a study published in the American Journal of Transplantation".

Communities Weekly Rewind: Are We Underutilizing Hepatitis-C Donor Kidneys?

Primary Query

Can we safely utilize hepatitis C Virus seropositive non viremic donor kidneys (HCV Ab positive/NAT negative) for hepatitis C Virus non viremic recipients?

Communities Weekly Rewind: Thin Basement Membrane Nephropathy and Kidney Donation

Introduction and Background
A 45 year old white male wishes to donate a kidney.  He has a history of persistent hematuria with no proteinuria and a normal blood pressure.  Kidney biopsy revealed thin basement membrane nephropathy (TBMN). He has no family history of kidney disease, hearing loss or lenticonus.

OPTN Proposing Contentious Changes to Long-Standing Policy Creation Process

Recently, the Organ Procurement Transplant Network / United Network for Organ Sharing (OPTN / UNOS) executive committee published a concept paper[i] which is currently under public comment.  The paper proposes that the current committee structure utilized to develop and implement policy should be drastically altered.

Communities Weekly Rewind: Donor Evaluation

Query

A person with history of coronary artery disease, coronary artery bypass grafting (CABG) and no other comorbidities is being evaluated as a potential kidney donor. Stress test (TMT) and stress echocardiography are currently normal.  Can such a person be considered for kidney donation? If not, are there any guidelines and what other factors should be considered?

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