Diabetes & Metabolism

First CRISPR Clinical Trial Receives Advisory Panel Approval

First CRISPR clinical trial could start by the end of this year.

Re-Energizing Nephrology: TPD Retreat 2016

The 2016 ASN Training Program Directors’ Retreat focused on new ways to re-energize the specialty and attract trainees to nephrology.

Nephrology Fellows' View

Dr. Lilia Maria Rizo Topete (Monterrey, Mexico) shares one of her memorable training experiences.

ASN Names Next Editor-in-Chief of CJASN

ASN has named Rajnish Mehrotra, MD, FASN, as CJASN Editor-in-Chief effective January 1, 2017. He will serve a six-year term.

Communities at ASN

ASN Communities offer multiple opportunities to connect with colleagues working in the areas that interest you most. Check out this rapidly growing and dynamic ASN initiative here.

High Fructose Corn Syrup May Be More Toxic than Table Sugar

In mice that were fed sugar in doses proportional to what many people eat, a fructose-glucose mixture found in high-fructose corn syrup was more toxic than sucrose or table sugar in females, increasing their death rates by 1.9-times and reducing their reproductive capacity by 26%. No differences were seen in males. Both high-fructose corn syrup and table sugar contain roughly equal amounts of fructose and glucose, but they exist as separate molecules, or monosaccharides, in corn syrup. In sucrose or table sugar, they exist as a disaccharide compound.

Genetic Markers in Mice and Humans Linked with Obesity

By analyzing epigenetic markers, or chemical tags, at more than 7 million sites in the DNA of the fat cells in mice, researchers found clear differences between normal and obese mice—and they found a similar pattern in human cells. Some of the epigenetic changes associated with obesity affect genes already known to raise diabetes risk. Others affect genes that had not been conclusively linked to the disease, but that have roles in metabolism. Some of the genes regulate insulin action on sugar uptake, making them potential targets for treating type 2 diabetes.

Type 1 Diabetes May Shorten Life Expectancy, But Early Intensive Treatment May Help Restore Lost Years

At age 20, men with type 1 diabetes have an estimated loss of life expectancy of 11 years; for women, it’s a loss of 13 years compared with nondiabetics. The JAMA findings come from an analysis of individuals in Scotland with type 1 diabetes who were ≥20 years old from 2008 through 2010 and were in a nationwide register.

Elevated Blood Sugar May Increase Heart Failure Patients’ Risk of Early Death

Among 16,524 patients with acute heart failure syndrome who presented to the emergency department, those with blood glucose levels between 6.1 and 7.8 mmol/L had a 26% higher risk of death within 30 days from any cause, a 28% higher risk of death from cardiovascular causes, and a 61% higher risk of diabetes compared with a reference group of patients with blood glucose levels between 3.9 and 6.1 mmol/L.

Genetic Variations in Magnesium-Related Ion Channels May Affect Diabetes Risk

Interactions of diet, genetics, and ethnicity may affect magnesium-mediated diabetes risk, according to a new study. After identifying 17 magnesium-related ion channel genes, investigators examined whether variations in the genes were associated with type 2 diabetes risk in 7287 African-American and 3285 Hispanic-American postmenopausal women. Several variants stood out in the Journal of Nutrition study.

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