Does Contrast Exposure Cause Contrast-Induced AKI?

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Contrast media exposure is not a “primary pathogenetic factor” in the development of acute kidney injury (AKI) after primary angioplasty, reports a study in the open-access Journal of the American Heart Association.

The researchers analyzed 2025 patients with ST segment-elevation myocardial infarction (STEMI) who underwent primary percutaneous coronary intervention at an Israeli hospital between 2000 and 2015. Median contrast dose was 150 mL. Rates of AKI were compared with those of 1025 patients undergoing fibrinolysis or no reperfusion therapy, who were not exposed to contrast medium. Acute kidney injury was defined as a creatinine level of 0.5 mg/dL