Ibuprofen May Increase AKI Risk in Ultramarathon Runners

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Acute kidney injury (AKI) may be more frequent in ultramarathon runners who take ibuprofen, according to a randomized controlled trial in Emergency Medicine Journal.

The study included 91 athletes participating in 50-mile ultramarathon races in desert environments. Runners were randomly assigned to take ibuprofen 400 mg or placebo tablets every 4 hours during their race. Incidence of AKI was compared between groups: “risk” was defined as a 1.5-fold increase in creatinine and “injury” as a twofold increase. Runner characteristics were similar between groups; in the ibuprofen group, average total dose was 1200 mg.

Overall AKI incidence was 44%.