APOL1 Improves Risk Prediction in African American Deceased Donors

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A revised Kidney Donor Risk Index (KDRI) incorporating APOL1 genotype rather than race improves prediction of allograft survival of kidneys from African American deceased donors, reports a study in American Journal of Transplantation.

The study included data on 622 African American deceased kidney donors from three southern US centers. The researchers used a series of models to analyze the impact of a revised KDRI substituting APOL1 genotype for race.

For all donors, mean current KDRI was 1.4930. With the revised KDRI, the risk score decreased to 1.2518 for 529 donors with no or one