YAP Protein Emerging As Key Player in Kidney Health, Disease

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Necessity is the mother of invention for physician-scientists like Darren Yuen, MD, PhD, a nephrologist at St. Michael’s Hospital in Toronto. Frustrated with the lack of treatment options for the progressive scarring in the kidney called fibrosis, he turned to his lab in search of a new anti-fibrotic agent.

His team is among a cohort of researchers who have studied the fibrotic effects of a protein called TGF-β for decades, but so far that work has not yielded new treatments.

“TGF-β hasn’t panned out as a treatment target in kidney patients because it does a lot