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Advancing Our Understanding of Glomerular Disease Through Omics

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The word omics or multiomics refers to high-throughput agnostic methods commonly used in systems biology and systems genetics. Systems genetics is a relatively new approach that combines a range of experimental and computational methods to quantify and integrate genetic effects across intermediate phenotypes, such as transcript, protein, or metabolite levels, in order to better understand the flow of genetic information through cellular regulatory networks. This approach studies the effects of DNA variants (genome) on RNA transcription (transcriptome), protein synthesis (proteome), metabolic functions (metabolome), and ultimately, disease phenotype (phenome). These approaches are ideally suited to study multifactorial traits with complex genetic